منابع مشابه
Synergistic Effects of Arsenic Trioxide and Radiation: Triggering the Intrinsic Pathway of Apoptosis
Background: Arsenic trioxide (ATO) has been reported as an effective anti-cancer and a US Food and Drug Administration (FDA) approved drug for treatment of some cancers. The aim of this study is to determine the underlying apoptosis molecular and cellular mechanisms of ATO in the presence or absence of ionizing radiation (IR) in vitro in the glioblastoma multiforme (GBM) cell line, U87MG. Metho...
متن کاملHydatid Cyst Killing Mechanism of Ziziphora tenuior by Inducing Apoptosis via Mitochondrial Intrinsic Pathway
Background and objectives: Ziziphora tenuior is considered as an appropriate protoscolicidal agent yet the mechanism of such effect is not known so far. The aim of this study was to evaluate the apoptotic effect of Z. tenuior extract on protoscolices of hydatid cyst. Methods: Protoscolices were collected aseptically and the Bradford test was e...
متن کاملExtrinsic and Intrinsic Apoptosis Signal Pathway Review
Apoptosis, as a programmed cell death (PCD) is essential for normal cell mechanism. The word “Apoptosis” derives from Greek language “απόπτωσις” and means trees shedding their leaves in autumn, which describes the "dropping off" or "falling off" of petals from flowers, or leaves from trees. This language imaginarily described the cell death triggered by physiological and pathological stimulatio...
متن کاملP-107: Intrinsic Apoptosis Pathway Involvement in Mouse Testicular Tissue Degeneration after Vitrification and Short-Term Culture
Background: Although testicular tissue cryopreservation could be advantageous for fertility preservation in cancerous children, the possibility of apoptosis incidence should not be ignored. Our aim was evaluation of the apoptosis incidence in mouse testicular tissue after vitrification and short-term culture. Materials and Methods: Testes of 7days old NMRI male mice were isolated, divided and d...
متن کاملmiR-24 Regulates Intrinsic Apoptosis Pathway in Mouse Cardiomyocytes
Numerous cardiac diseases, including myocardial infarction (MI) and chronic heart failure, have been associated with cardiomyocyte apoptosis. Promoting cell survival by inhibiting apoptosis is one of the effective strategies to attenuate cardiac dysfunction caused by cardiomyocyte loss. miR-24 has been shown as an anti-apoptotic microRNA in various animal models. In vivo delivery of miR-24 into...
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ژورنال
عنوان ژورنال: Reactome - a curated knowledgebase of biological pathways
سال: 2004
ISSN: 1934-1792
DOI: 10.3180/react_964.1